Found: The dial in the brain that controls the immune system

{
  "by": "andreareina",
  "descendants": 4,
  "id": 40243417,
  "kids": [
    40243718,
    40244904,
    40245202
  ],
  "score": 45,
  "time": 1714703500,
  "title": "Found: The dial in the brain that controls the immune system",
  "type": "story",
  "url": "https://www.nature.com/articles/d41586-024-01259-2"
}

{
  "author": "Giorgia Guglielmi",
  "date": "2024-05-01T00:00:00.000Z",
  "description": "Scientists identify the brain cells that regulate inflammation, and pinpoint how they keep tabs on the immune response.",
  "image": "https://media.nature.com/lw1200/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_27034294.jpg",
  "logo": null,
  "publisher": "Nature",
  "title": "Found: the dial in the brain that controls the immune system",
  "url": "https://www.nature.com/articles/d41586-024-01259-2"
}

{
  "url": "https://www.nature.com/articles/d41586-024-01259-2",
  "title": "Found: the dial in the brain that controls the immune system",
  "description": "Scientists identify the brain cells that regulate inflammation, and pinpoint how they keep tabs on the immune response. Scientists identify the brain cells that regulate inflammation, and pinpoint how they keep tabs on the immune response.",
  "links": [
    "https://www.nature.com/articles/d41586-024-01259-2"
  ],
  "image": "https://media.nature.com/lw1200/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_27034294.jpg",
  "content": "<div>\n                    <article>\n<div>\n        <div>\n            <ul>\n                <li><span>NEWS</span></li>\n                <li>01 May 2024</li>\n            </ul>\n            <div>\n                <p>\n                    Scientists identify the brain cells that regulate inflammation, and pinpoint how they keep tabs on the immune response.\n                </p>\n            </div>\n        </div>\n            <div>\n                <p><span>By</span></p><ul>\n        <li>\n            <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-01259-2#author-0\">\n                Giorgia Guglielmi</a><sup><a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-01259-2#Aff0\">0</a></sup></li>\n</ul>\n<div>\n    <ol>\n            <li>\n                    <span>Giorgia Guglielmi</span>\n                    <ol>\n                        <li>\n                            <p>Giorgia Guglielmi is a science journalist in Basel, Switzerland.</p>\n                        </li>\n                    </ol>\n                    <div>\n                            <div><p><a target=\"_blank\" href=\"https://www.nature.com/search?author=Giorgia+Guglielmi\">View author publications</a></p></div>\n                            <div>\n                                <p>\n                                    <span>Search author on:</span>\n                                    <span><a target=\"_blank\" href=\"http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&amp;term=Giorgia+Guglielmi\">PubMed</a>\n                                    <span> </span><a target=\"_blank\" href=\"https://scholar.google.co.uk/scholar?as_q=&amp;btnG=Search+Scholar&amp;as_sauthors=%22Giorgia%2BGuglielmi%22\">Google Scholar</a>\n                                    </span></p>\n                            </div>\n                       </div>\n            </li>\n    </ol>\n</div>\n            </div>\n    <div>\n        <ul>\n    <li>\n        <a target=\"_blank\" href=\"mailto:?subject=Found:%20the%20dial%20in%20the%20brain%20that%20controls%20the%20immune%20system&amp;body=https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-024-01259-2\">\n            <span>Email</span>\n        </a>\n    </li>\n    <li>\n        <a target=\"_blank\" href=\"https://bsky.app/intent/compose?text=Found%3A+the+dial+in+the+brain+that+controls+the+immune+system%20https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-024-01259-2\">\n            <span>Bluesky</span>\n        </a>\n    </li>\n    <li>\n        <a target=\"_blank\" href=\"https://www.facebook.com/sharer.php?u=https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-024-01259-2&amp;t=Found%3A+the+dial+in+the+brain+that+controls+the+immune+system\">\n            <span>Facebook</span>\n        </a>\n    </li>\n    <li>\n        <a target=\"_blank\" href=\"https://www.linkedin.com/shareArticle?text=Found%3A+the+dial+in+the+brain+that+controls+the+immune+system&amp;url=https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-024-01259-2\">\n            <span>LinkedIn</span>\n        </a>\n    </li>\n    <li>\n        <a target=\"_blank\" href=\"https://www.reddit.com/submit?title=Found%3A+the+dial+in+the+brain+that+controls+the+immune+system&amp;url=https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-024-01259-2\">\n            <span>Reddit</span>\n        </a>\n    </li>\n    <li>\n        <a target=\"_blank\" href=\"https://wa.me/?text=Found%3A+the+dial+in+the+brain+that+controls+the+immune+system%20https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-024-01259-2\">\n            <span>Whatsapp</span>\n        </a>\n    </li>\n    <li>\n        <a target=\"_blank\" href=\"https://twitter.com/intent/tweet?text=Found%3A+the+dial+in+the+brain+that+controls+the+immune+system&amp;url=https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-024-01259-2\">\n            <span>X</span>\n        </a>\n    </li>\n</ul>\n    </div>\n</div>\n                    <div>\n            <p>\n                <a target=\"_blank\" href=\"https://wayf.springernature.com/?redirect_uri=https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-024-01259-2\">\n                    <span>Access through your institution</span>\n                </a>\n            </p>\n                <div>\n                    <p><a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-01259-2#access-options\">\n                        <span>Buy or subscribe</span>\n                    </a>\n                </p></div>\n        </div>\n                    <p>Scientists have long known that <a target=\"_blank\" href=\"https://doi.org/10.1038/d41586-023-00509-z\">the brain plays a part in the immune system</a> — but how it does so has been a mystery. Now, scientists have identified cells in the brainstem that sense <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-021-01396-y\">immune cues from the periphery of the body</a> and act as master regulators of the body’s <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-00871-6\">inflammatory response</a>.</p>\n                    <div>\n                        <h2 id=\"access-options\">Access options</h2>\n        <div>\n            <p>\n                <a target=\"_blank\" href=\"https://wayf.springernature.com/?redirect_uri=https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-024-01259-2\">\n                    <span>Access through your institution</span>\n                </a>\n            </p>\n        </div>\n    <section><div>\n      <p>\n        Access Nature and 54 other Nature Portfolio journals\n      </p>\n      <p>\n        Get Nature+, our best-value online-access subscription\n      </p>\n      <div>\n        <p>\n          <span>$32.99<span> / 30 days</span></span>\n        </p>\n        <p>cancel any time</p>\n      </div>\n      <div>\n        <p><a target=\"_blank\" href=\"https://shop-amers.nature.com/products/plus/?region=US\"><span>Learn more</span></a>\n      </p></div>\n    </div><div>\n      <p>Subscribe to this journal</p>\n      <p>\n        Receive 51 print issues and online access\n      </p>\n    <div>\n      <p>$199.00 per year</p>\n      <p>only $3.90 per issue</p>\n    </div>\n    <div>\n      <p><a target=\"_blank\" href=\"https://www.nature.com/nature/subscribe\"><span>Learn more</span></a>\n    </p></div>\n    </div><div>\n      <p>Rent or buy this article</p>\n      <p>Prices vary by article type</p>\n      <p><span>from</span>$1.95</p>\n      <p><span>to</span>$39.95</p>\n      <div>\n        <p><a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-01259-2.epdf?no_publisher_access=1&amp;r3_referer=nature\"><span>Learn more</span></a>\n      </p></div>\n    </div><p>Prices may be subject to local taxes which are calculated during checkout</p></section>\n    <h3>Additional access options:</h3>\n    <ul>\n        <li>\n            <a target=\"_blank\" href=\"https://idp.nature.com/authorize/natureuser?client_id=grover&amp;redirect_uri=https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-024-01259-2\">Log in</a>\n        </li>\n        <li>\n            <a target=\"_blank\" href=\"https://www.springernature.com/gp/librarians/licensing/license-options\">Learn about institutional subscriptions</a>\n        </li>\n        <li>\n            <a target=\"_blank\" href=\"https://support.nature.com/en/support/home\">Read our FAQs</a>\n        </li>\n        <li>\n            <a target=\"_blank\" href=\"https://www.springernature.com/gp/contact\">Contact customer support</a>\n        </li>\n    </ul>\n                    </div>\n                <p><em>doi: https://doi.org/10.1038/d41586-024-01259-2</em></p>\n            <div><h2 id=\"Bib1\">References</h2><div><ol><li><p>Jin, H., Li, M., Jeong, E., Castro-Martinez, F. &amp; Zuker, C. S. <i>Nature</i> https://doi.org/10.1038/s41586-024-07469-y (2024).</p><p><a target=\"_blank\" href=\"https://doi.org/10.1038%2Fs41586-024-07469-y\">Article</a> \n    <a target=\"_blank\" href=\"http://scholar.google.com/scholar_lookup?&amp;title=&amp;journal=Nature&amp;doi=10.1038%2Fs41586-024-07469-y&amp;publication_year=2024&amp;author=Jin%2CH.&amp;author=Li%2CM.&amp;author=Jeong%2CE.&amp;author=Castro-Martinez%2CF.&amp;author=Zuker%2CC.%20S.\">\n                    Google Scholar</a> \n                </p></li></ol><p><a target=\"_blank\" href=\"https://citation-needed.springer.com/v2/references/10.1038/d41586-024-01259-2?format=refman&amp;flavour=references\">Download references</a></p></div></div>\n                <div>\n                    <p><a target=\"_blank\" href=\"https://s100.copyright.com/AppDispatchServlet?title=Found%3A%20the%20dial%20in%20the%20brain%20that%20controls%20the%20immune%20system&amp;author=Giorgia%20Guglielmi&amp;contentID=10.1038%2Fd41586-024-01259-2&amp;copyright=Springer%20Nature%20Limited&amp;publication=0028-0836&amp;publicationDate=2024-05-01&amp;publisherName=SpringerNature&amp;orderBeanReset=true\">Reprints and permissions</a></p>\n                </div>\n                <h2 id=\"related-articles\">Related Articles</h2>\n    <ul>\n            <li>\n                <p>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-023-00509-z\">\n                            <img src=\"https://media.nature.com/lw100/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_24096670.jpg\" />\n                        Your brain could be controlling how sick you get — and how you recover\n                    </a>\n                </p>\n            </li>\n            <li>\n                <p>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-022-01502-8\">\n                            <img src=\"https://media.nature.com/lw100/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_24045344.jpg\" />\n                        Guardians of the brain: how a special immune system protects our grey matter\n                    </a>\n                </p>\n            </li>\n            <li>\n                <p>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-00169-7\">\n                            <img src=\"https://media.nature.com/lw100/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_26671374.jpg\" />\n                        Can autoimmune diseases be cured? Scientists see hope at last\n                    </a>\n                </p>\n            </li>\n            <li>\n                <p>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-023-00584-2\">\n                            <img src=\"https://media.nature.com/lw100/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_24096666.jpg\" />\n                        Anxiety can be created by the body, mouse heart study suggests\n                    </a>\n                </p>\n            </li>\n    </ul>\n                <h2 id=\"subjects\">Subjects</h2>\n    <ul>\n            <li>\n                <a target=\"_blank\" href=\"https://www.nature.com/subjects/brain\">Brain</a>\n            </li>\n            <li>\n                <a target=\"_blank\" href=\"https://www.nature.com/subjects/immunology\">Immunology</a>\n            </li>\n            <li>\n                <a target=\"_blank\" href=\"https://www.nature.com/subjects/neuroscience\">Neuroscience</a>\n            </li>\n    </ul>\n            <section>\n    <h2 id=\"tablist-heading\">Latest on:</h2>\n    <ul>\n            <li>\n                <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-01259-2#latest-content-0-container\">Brain</a>\n            </li>\n            <li>\n                <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-01259-2#latest-content-1-container\">Immunology</a>\n            </li>\n            <li>\n                <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-01259-2#latest-content-2-container\">Neuroscience</a>\n            </li>\n    </ul>\n    <section>\n        <ul>\n                <li>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-026-00062-5\">\n                            <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-026-00062-5/d41586-026-00062-5_51926634.jpg\" />\n                        <p>Can’t get motivated? This brain circuit might explain why — and it can be turned off</p>\n                        <p><span>News</span> <span>09 JAN 26</span></p>\n                    </a>\n                </li>\n                <li>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-025-03987-5\">\n                            <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-025-03987-5/d41586-025-03987-5_51848894.png\" />\n                        <p>Chronic pain could be eased by uncoupling the sensory and emotional experiences</p>\n                        <p><span>News &amp; Views</span> <span>07 JAN 26</span></p>\n                    </a>\n                </li>\n                <li>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-025-04133-x\">\n                            <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-025-04133-x/d41586-025-04133-x_51836886.jpg\" />\n                        <p>How common is Alzheimer’s? Blood-test study holds surprises</p>\n                        <p><span>News</span> <span>17 DEC 25</span></p>\n                    </a>\n                </li>\n        </ul>\n    </section>\n    <section>\n        <ul>\n                <li>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-025-04154-6\">\n                            <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-025-04154-6/d41586-025-04154-6_51909584.jpg\" />\n                        <p>Will mpox go global again? Research shows it’s evolving in curious ways</p>\n                        <p><span>News</span> <span>08 JAN 26</span></p>\n                    </a>\n                </li>\n                <li>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-026-00007-y\">\n                            <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-026-00007-y/d41586-026-00007-y_51921604.jpg\" />\n                        <p>Huge Chinese cell atlas reveals surprising immune variation among peoples</p>\n                        <p><span>News</span> <span>08 JAN 26</span></p>\n                    </a>\n                </li>\n                <li>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-025-03985-7\">\n                            <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-025-03985-7/d41586-025-03985-7_51848946.png\" />\n                        <p>Blood protein thwarts deadly fungal disease</p>\n                        <p><span>News &amp; Views</span> <span>07 JAN 26</span></p>\n                    </a>\n                </li>\n        </ul>\n    </section>\n    <section>\n        <ul>\n                <li>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-026-00062-5\">\n                            <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-026-00062-5/d41586-026-00062-5_51926634.jpg\" />\n                        <p>Can’t get motivated? This brain circuit might explain why — and it can be turned off</p>\n                        <p><span>News</span> <span>09 JAN 26</span></p>\n                    </a>\n                </li>\n                <li>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/s41586-025-09902-2\">\n                            <img src=\"https://media.nature.com/w140h79/springer-static/image/art%3A10.1038%2Fs41586-025-09902-2/MediaObjects/41586_2025_9902_Fig1_HTML.png\" />\n                        <p>Prefrontal neural geometry of learned cues guides motivated behaviours</p>\n                        <p><span>Article</span> <span>07 JAN 26</span></p>\n                    </a>\n                </li>\n                <li>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/s41586-025-09910-2\">\n                            <img src=\"https://media.nature.com/w140h79/springer-static/image/art%3A10.1038%2Fs41586-025-09910-2/MediaObjects/41586_2025_9910_Fig1_HTML.png\" />\n                        <p>Distinct neuronal populations in the human brain combine content and context</p>\n                        <p><span>Article</span> <span>07 JAN 26</span></p>\n                    </a>\n                </li>\n        </ul>\n    </section>\n</section>\n            <div>\n        <div>\n            <h2>\n                <img src=\"https://www.nature.com/static/images/logos/nature-careers-logo-f6ff1c1c64.svg\" alt=\"Nature Careers\" />\n            </h2>\n        </div>\n        <h3>\n            <a target=\"_blank\" href=\"https://www.nature.com/naturecareers/\">Jobs\n            </a>\n        </h3>\n        <ul>\n                <li>\n                    <div>\n                        <h4><a target=\"_blank\" href=\"https://www.nature.com/naturecareers/job/12852566/postdoctoral-researcher-in-human-intestinal-tumor-and-inflammation-research/?TrackID=62&amp;utm_source=widget&amp;utm_medium=referral&amp;utm_campaign=62\">Postdoctoral Researcher in human intestinal tumor- and inflammation research</a></h4>\n                        <div>\n                            <p>Do you want to contribute to top quality medical research? We are looking for an ambitious postdoc with solid human immunology skills to join our high</p>\n                            <p>Huddinge</p>\n                            <p>Karolinska Institutet (KI)</p>\n                        </div>\n                    </div>\n                        <p><img src=\"https://www.nature.com/naturecareers/getasset/ad64cfe9-bc2d-4f35-84c0-28fe7b3dbd2e/\" />\n                        </p>\n                </li>\n                <li>\n                    <div>\n                        <h4><a target=\"_blank\" href=\"https://www.nature.com/naturecareers/job/12843442/institute-of-nanotechnology-and-intelligence-global-recruitment-for-outstanding-young-scientists/?TrackID=62&amp;utm_source=widget&amp;utm_medium=referral&amp;utm_campaign=62\">Institute of Nanotechnology And Intelligence Global Recruitment for Outstanding Young Scientists</a></h4>\n                        <div>\n                            <p>Exceptional young scholars worldwide with strong research achievements in relevant fields</p>\n                            <p>Guangzhou, Guangdong (CN)</p>\n                            <p>Institute of Nanotechnology and Intelligence (inAI), Jinan University, China.</p>\n                        </div>\n                    </div>\n                        <p><img src=\"https://www.nature.com/naturecareers/getasset/0a43a3c0-751e-4c63-b562-e4817a784363/\" />\n                        </p>\n                </li>\n                <li>\n                    <div>\n                        <h4><a target=\"_blank\" href=\"https://www.nature.com/naturecareers/job/12848708/high-level-talent-at-the-major-agricultural-microbiology-research-facility-of-hzau/?TrackID=62&amp;utm_source=widget&amp;utm_medium=referral&amp;utm_campaign=62\">High-Level Talent at the Major Agricultural Microbiology Research Facility of HZAU</a></h4>\n                        <div>\n                            <p>Join HZAU's global faculty team to advance research with competitive benefits.</p>\n                            <p>No.1 Shizishan Street, Hongshan District, Wuhan, Hubei Province, China</p>\n                            <p>Huazhong Agricultural University (HZAU)</p>\n                        </div>\n                    </div>\n                        <p><img src=\"https://www.nature.com/naturecareers/getasset/0cbac729-18c4-4ffc-a399-1725cb26824b/\" />\n                        </p>\n                </li>\n                <li>\n                    <div>\n                        <h4><a target=\"_blank\" href=\"https://www.nature.com/naturecareers/job/12851536/assistant-associate-professor-of-pediatrics-neonatology-/?TrackID=62&amp;utm_source=widget&amp;utm_medium=referral&amp;utm_campaign=62\">Assistant/Associate/Professor of Pediatrics (Neonatology)</a></h4>\n                        <div>\n                            <p>The University of Illinois College of Medicine Peoria seeks a board-certified or board-eligible Neonatologist</p>\n                            <p>Peoria, Illinois</p>\n                            <p>University of Illinois College of Medicine Peoria</p>\n                        </div>\n                    </div>\n                </li>\n                <li>\n                    <div>\n                        <h4><a target=\"_blank\" href=\"https://www.nature.com/naturecareers/job/12851531/postdoctoral-researcher-in-translational-cancer-research-blood-and-prostate-cancer-/?TrackID=62&amp;utm_source=widget&amp;utm_medium=referral&amp;utm_campaign=62\">Postdoctoral Researcher in Translational Cancer Research (blood and prostate cancer)</a></h4>\n                        <div>\n                            <p>Department of Pathology, Albert Einstein College of Medicine, Bronx, NY The Verma Laboratory in the Department of Pathology at Albert Einstein Coll...</p>\n                            <p>Bronx, New York 10461 United States</p>\n                            <p>Albert Einstein College of Medicine</p>\n                        </div>\n                    </div>\n                </li>\n        </ul>\n            </div>\n                    </article>\n                </div>",
  "author": "Guglielmi, Giorgia",
  "favicon": "https://www.nature.com/static/images/favicons/nature/favicon.ico",
  "source": "nature.com",
  "published": "2024-05-01",
  "ttr": 121,
  "type": "article"
}